Endocrine Abstracts

PANCH tumour (pituitary adenoma with neuronal choristoma), is a very rare form of pituitary pathology composed of a mixed pituitary adenoma/gangliocytoma. We describe a patient with acromegaly who had evidence of GH synthesis in the neuronal component of a PANCH tumour. A 55-year-old woman was found to have facial features of acromegaly, confirmed biochemically: basal GH 13.56 ng/ml, GTT nadir 8.87 ng/ml, and IGF1 raised at 97.2 nmol/l (ref 9–40). Pituitary function was o...

Introduction: We present two pregnant women who were referred to obstetric endocrinology service with polyuria and polydipsia. They were investigated and treated for diabetes insipidus (DI). In both cases, the underlying pathophysiology was ADH insufficiency secondary to autoimmune lymphocytic hypophysitis. There are currently no consensus guidelines on the diagnosis of DI during pregnancy. These cases highlight best practice and endorse MDT management of chronic hypopituitari...

Introduction: Association between lymphoma and pituitary dysfunction is well documented, though most commonly through mechanism of infiltrative pituitary metastasis, or primary lymphoma of the pituitary, rather than autoimmune lymphocytic hypophysitis. Here we present a highly unusual case whereby investigation into the cause of Diabetes Insipidus with radiological features of lymphocytic hypophysitis, led to diagnosis and cure of Diffuse Large B-cell lymphoma (DLBCL). Diabete...

A 28-year-old female presented to the optician with visual disturbance, lethargy and headaches, which were initially attributed to long hours of IT work. Despite a trial of eye exercises she experienced worsening colour vision and acuity in the right eye, hence a further consultation with an optometrist. Examination did not reveal a visual field defect. Visual acuity was 6/6 with 9/17 ishihara plates in the right eye and 5/6 with 17/17 ishihara plates in the left. A further re...